Jaw Imlpant Befor And After

The drug is male, she is likely different effects

The drugs are almost always a measure of man, that he tested primarily on men. "Discrimination" begins in pre-clinical phase of testing, ie when the molecule experiments on mice, almost always male.
And the results are good, women have almost twice as adverse drug events than males, and often it is the most serious adverse events. E ' As reported by Flavia Franconi, professor of the Department of Pharmaceutical Sciences University of Sassari, which took place in Paris at the meeting Gender, Science and Technology, organized by the UN and UNESCO to discuss the problem of the many 'Discrimination' kind of hidden in everyday life and their effects on women's health.
"The problem of testing drugs is long, Franconi says: The fact is that female mice are more 'inconvenient' to use force because having the estrous cycle to include more variables in the experiment. Moreover, when used, the female guinea pig are taken too young, that is when they have never had a pregnancy, but this Franconi stresses, changes everything because the drugs, on average, are prescribed mainly adult women who have had children and "hormonal storm" that occurs after pregnancy change much feminine body and its response to drugs. "
Even in clinical trials must be better, although there was a partial improvement: among volunteers enrolled in phase I and II only 30% women; for the last experimental phase, phase III, we have reached today is almost a a tie for men and women among the volunteers, except for some drugs such as cardiovascular diseases.
"The most forgotten is the older woman - said Franconi - especially if you take hormone therapies that can interfere with other drugs. "And then also the fertile woman taking contraceptives (30% of women use the pill): the drugs on the market for various indications are not tested studying possible interactions with the contraceptive, which, however, affect the metabolism of other drugs .
no coincidence that the woman is exposed to almost double the number of adverse effects from drugs than men, and they are on average more severe events. And then there is the problem of drug doses, study on a man 70 kilos, but she weighs a lot less. It even already in children the effects of a drug differ by gender.
The problem is that the male body metabolizes drugs differently than women and is supposed to in some cases even the drug has a different mode of action in both sexes. Women take more medications on average than men, Franconi concludes, is the 'paradox of woman', who live longer but get sick more. So it is good that there are differences of gender and age in the trials. Editorial

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